Open February 17th, 2021 through Friday, Mar 19, 2021 at 11:59pm (Pacific Time)
Applications are sought for a full-time Assistant Project Scientist position. The successful candidate will work as part of an interdisciplinary research team in the laboratory of Dr. Kathrin Plath’s Lab in the UCLA Department of Biological Chemistry. The focus of the Plath Lab is on understanding the gene regulatory mechanisms underlying cellular plasticity and differentiation will open the door to manipulate cell identity and gene expression states and to understand disease processes. To uncover such mechanisms, the studies in the lab are informed by two key processes: the reprogramming of somatic cells to the pluripotent state and the regulation of nuclear compartments and gene expression by long non-coding RNAs (lncRNAs).
This position is intended for collaborative research working on single cell RNA and ATAC sequencing technologies and lineage tracing methods to investigate mechanisms underlying cell fate change, with a focus on being able to accomplish both experimental procedures and also develop sophisticated computational analyses. The Plath lab has described many detailed molecular mechanisms that occur during conversion of somatic cells towards induced pluripotent stem cells and is looking to deeply understand the stochastic mechanisms that induce the pluripotent state in somatic cells. In addition, the person hired into this position will lead collaborations with other labs on applying single cell genomics approaches and the computational analysis of the data.
A successful candidate(s) will have the following qualifications:
• PhD in a Biological or Computational Discipline
• Ability to work in a collaborative interdisciplinary environment
• Expertise in computational analysis of single cell genomics data sets
• Experience working with and analyzing chromatin assays such as ATAC-seq,
RRBS, ChIP-Seq etc.
• Experience in establishing new methods and approaches
• First author publication preferred
Job duties and responsibilities
• Participate in the planning of grant goals and gathering pilot data for such
• Responsible for writing grant proposals for submission to federal and private
• Responsible for writing research papers for publication
• Responsible for progress reporting to granting agencies
• Seek funding to establish own independence
• Responsible for supervising lab members including undergraduate students,
graduate students, postdocs, lab helpers and high school students
• Responsible for maintenance of lab instruments and training new users in
their operation (tissue culture equipment, microfluidics setups, sequencing
preparation machinery such as sonicators)
• Conduct research into cell identity and cell fate change mechanisms, using
single cell technologies, lineage tracing, and inventive analysis to describe
molecular mechanisms that occur during conversion of somatic cells towards
induced pluripotent stem cells and in the reverse process of differentiation
• Manage collaborative projects related to the study of developmental and
disease processes using single cell approaches
The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. UC Nondiscrimination & Affirmative Action Policy
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Please be advised that the final candidate recommended for hire into a critical (or otherwise designated) position will be required to successfully complete a background investigation. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
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