Open date: April 6th, 2021
Next review date: Tuesday, Apr 20, 2021 at 11:59pm (Pacific Time)
Apply by this date to ensure full consideration by the committee.
Final date: Wednesday, Jun 30, 2021 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
The Kelesidis Research Lab in the Division of Infectious Diseases, Department of Medicine at the David Geffen School of Medicine at UCLA is seeking applicants for a full-time, 2-year funded position by NIH, Project Scientist position at the Assistant rank. The incumbent will conduct research in novel therapeutic approaches to treat viral infections including HIV and Covid-19. The candidate should be comfortable working with BSL2+ biospecimens including biospecimens (cells, plasma) from patients with COVID019 and/or HIV. The individual will learn new laboratory procedures and techniques as needed.
Preferred qualifications: Familiar with techniques such as multi-color flow cytometry, sterile technique for cell culture with BSL-2+ practices, ELISA, qRT-PCR, immunofluorescence, Western Blot and molecular biology techniques. Experience in virology research. Experience with animal procedures (phlebotomy, injections, tissue dissections). Candidates with a strong background in molecular immunology and/or virology and or related discipline are strongly encouraged to apply. A Ph.D. is required.
Overview: The pandemic COVID-19 emphasized the need to develop novel therapeutic strategies to combat morbidity and mortality from viral infections. The Kelesidis laboratory focuses on novel antioxidants that target increased bioactive lipids and altered mitochondria to attenuate increased systemic inflammation, immune dysfunction and end organ disease in chronic HIV infection. Importantly these antioxidants were also recently shown to attenuate SARS-CoV-2 viral replication and associated inflammatory responses in lung cells. The lab uses in vitro cell culture models, ex vivo models of atherogenesis and gut explants to dissect mechanisms how the cross talk between bioactive lipids, immune, endothelial and epithelial cells drive atherogenesis and how novel therapeutic agents attenuate aberrant proinflammatory cellular pathways. The lab also uses a preclinical humanized mouse model of chronic treated HIV infection to study in vivo how novel therapies attenuate end organ disease. Recent areas of research include studies of pathogenesis of COVID-19 using preclinical in vitro and animal models of SARS-CoV-2 infection.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: UC Nondiscrimination and Affirmative Action Policy.
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