The Soragni laboratory in the Department of Medicine – Hematology/Oncology at UCLA, is recruiting two highly motivated Assistant Specialists with expertise in molecular biology, biochemistry or cellular biology.
The Soragni lab studies protein aggregation in cancer and focuses on the development of three-dimensional models to study tumor biology and perform high-throughput drug screenings. These one-year positions (with possibility for renewal) are suitable for individuals with a minimum of 2 years of previous research experience who are looking to gain further research skills in order to apply to grad school or med school.
The first research project is focused on establishing and characterizing 3D models of cutaneous dermofibromas from NF1 samples. The candidate will process primary samples, FACS-sort them and establish optimal growth conditions. A high-throughput drug screening will be performed on the established models to identify drug candidates. The second research project is focused on identifying aggregating proteins in cancer. The candidate will identify aggregating proteins, validate leads in cell culture and confirm aggregation in vitro by biophysical and imaging methods.
The candidates will undergo a period of training to become acquainted with the basic methodologies used in the lab which includes (but are not limited to): culturing tumor cells in 2D and 3D systems, FACS sorting, isolate biological material from the samples (DNA, RNA, proteins), high throughput drug assays, transfection, immunohistochemistry, generate samples for mass spec, protein aggregation assays, bright field, fluorescence and electron microscopy.
The candidates are also expected to work closely with other group members and train students and colleagues. They will also contribute to laboratory management tasks including lab safety and ordering.
Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period.
The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status, or other protected catefories covered by the UC nondiscrimination policy. For the complete University of California nondiscrimination and affirmative action policy see: UC Nondiscrimination and Affirmative Action Policy.
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