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The Deb Laboratory in the Division of Cardiology, Department of Medicine, at the David Geffen School of Medicine at UCLA is seeking an Assistant Project Scientist to lead research on the role of the methionine salvage pathway (MSP) and its metabolite in cardiovascular disease. This is an independent, research-intensive position within a well-funded, highly collaborative program supported by NIH grants. The successful candidate will investigate how MSP-dependent molecular and metabolic mechanisms regulate cardiac function, remodeling and organ repair, and will help translate these findings into therapeutic strategies. A Ph.D. or equivalent is required.

Key Responsibilities:

• Design, lead and execute research projects on the molecular mechanisms by which the methionine salvage pathway regulates cardiac metabolism and the cardiac epigenome in cardiovascular disease.
• Utilize and further develop genetically engineered mouse models of cardiovascular disease, including cell-type-specific conditional knockout models.
• Perform and interpret in vivo/in vitro isotope metabolic tracing, targeted and untargeted metabolomics, and energetics studies.
• Generate and analyze single-cell multi-omics sequencing, methylation sequencing and metabolomics datasets, integrating them with human heart failure cohort data.
• Establish and apply human iPSC-derived cardiomyocyte and organoid systems for mechanistic and target-validation studies.
• Prepare manuscripts, figures and conference presentations; contribute to grant applications and progress reports.
• Train and mentor graduate students, postdoctoral fellows and technicians.
• Contribute to collaborative projects on tissue repair and translational therapeutics.

Preferred Qualifications:

• Direct research experience with the cardiac metabolism research.
• Experience with mouse models and echocardiographic/hemodynamic phenotyping.
• Proficiency in standard molecular and biochemical techniques.
• Expertise in single-cell/single-nucleus multiome analysis and epigenomic profiling.
• Experience with stem cell, iPSC or organoid culture systems.
• Publications in high-impact journals in cardiovascular research, metabolism or cell biology.

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As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.

• “Misconduct” means any violation of the policies or laws governing conduct at the applicant’s previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, discrimination, dishonesty, or unethical conduct, as defined by the employer.
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